About the journal
Allergologia et Immunopathologia Vol.37 Núm. 05
Allergologia et Immunopathologia. ISSN:0301-0546
Allergologia et Immunopathologia
The connection between early life wheezing and subsequent asthma: The viral march
jueves, 29 oct 2009
Por F.D. Martinez a
Several longitudinal studies have provided convincing evidence that, in most cases of asthma, the first symptoms of the disease occur during the preschool years.1,2< ...
Allergol Immunopathol (Madr).2009; 37(05) :249-51
Palabras clave: Asthma. Wheezing. Epidemiology. Virus. Viral march.
The connection between early life wheezing and subsequent asthma: The viral march
jueves, 29 oct 2009
Abstract
Several new lines of evidence suggest that alterations in immune responses which predispose to bronchial obstruction during acute respiratory infection, especially with rhinoviruses, may explain to a considerable extent the link between early life wheezing and subsequent asthma; above all among those schoolchildren who are prone to having recurrent asthma exacerbations. The nature of these alterations is currently the subject of considerable scrutiny, but cross-sectional studies suggest that deficits in innate immune responses mediated by interferon type I and III are present in lung macrophages and epithelial cells of adult asthmatics. Similarly, long-term follow-up studies suggest that deficits in interferon gamma responses in the first year of life predispose to recurrent episodes of wheezing from the preschool years and into early adolescence. A better understanding of the “viral march” could yield new therapeutic approaches for the prevention and treatment of acute severe airway obstruction during childhood.
Allergol Immunopathol (Madr).2009; 37(05) :249-51
Keywords: null
Envio Sumarios
